6 insights in this topic
This work shows that photoredox catalysis can deliver living, sequence-controlled fluoropolymerization under mild conditions. By using light to regulate radical activity, the authors achieve unprecedented control over polymer structure and properties, positioning photoredox chemistry as a powerful tool for precision materials synthesis.
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This work demonstrates a powerful photoredox-enabled strategy for the asymmetric functionalization of amino acids via hydrogen atom transfer–driven radical chemistry. By combining broad substrate scope, high stereocontrol, and scalability, the study highlights the growing maturity of photoredox catalysis as a practical tool for complex molecule synthesis.
This work demonstrates that intramolecular pi stacking can be used as a simple structural design strategy to control light-induced ligand release in Ru(II) photocages. By introducing subtle geometric distortion, dissociative excited states become more accessible, leading to dramatically enhanced ligand dissociation under visible light. The study highlights how small internal molecular interactions can produce large functional changes in photochemical reactivity.
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A simple photocatalytic system enables direct decarboxylative coupling of abundant carboxylic acids with alkenes, providing atom-economical routes to functionalized molecules.
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A novel photoredox approach for installing hydrocarbon staples into peptides yields cell-permeable inhibitors with enhanced proteolytic stability and binding affinity.
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Researchers demonstrate a new dual catalytic system combining nickel and photoredox catalysis to achieve direct C-H bond functionalization under mild conditions, opening pathways for late-stage drug modification.
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